Overview
Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities. This national randomized study will include 130 patients throughout 5 Danish cancer centres and investigate if a comprehensive geriatric intervention (CGA) when added upfront to SBRT for patients with localized NSCLC will have an impact on quality of life (QoL), overall survival, physical functionality and unplanned hospital admissions.
If an upfront CGA improves patients' general health status, this study could lead to implementation of a CGA in standard clinical practice as well as further research on older patients receiving radiotherapy.
Eligibility
Inclusion Criteria:
- Patients with cytologically or histologically proven non-small cell lung cancer
- Stage T1-3N0M0
- ≥ 70 years old
- In a multidisciplinary setting the patient is considered medically inoperable, too frail for operation due to age and/or comorbidity or that the patient refuse surgery and therefore candidate for SBRT.
Exclusion Criteria:
- Missing histology/cytology
- Another current malignancy
- Higher staging at treatment planning
- Not able to provide informed consent
- Do not speak or understand Danish