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Interpretation Bias as a Mechanism of Treatment Response in OCD

Interpretation Bias as a Mechanism of Treatment Response in OCD

Recruiting
18 years and older
All
Phase N/A

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Overview

This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I.

Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.

Eligibility

Inclusion Criteria:

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  1. OCD Institute patients

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2) adults (> 18 years old)

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3) able to complete a computer task for 20 minutes

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4) consent to main OCD Institute study protocol

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       5) primary diagnosis of OCD (as measured by a score of >16 on the Y-BOCS and a
          clinical diagnosis of OCD by their treatment team

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       6) score of >131 on the Obsessive Beliefs Questionnaire-44 at admission [which is
          1 SD above the mean score of the non-clinical sample reported in the original
          validation paper by the Obsessive Compulsive Cognitions Working Group (2005)]

Exclusion Criteria:

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  1. Currently experiencing acute symptoms of psychosis

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2) Psychotic disorder diagnosis

Study details
    Obsessive-Compulsive Disorder

NCT05224414

Mclean Hospital

21 May 2025

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