Overview
This study has the primary objective of investigating the benefits of consuming whole almonds on immune health and immune response in adults with obesity.
Description
The study is a six week, randomized, controlled, and parallel arm clinical trial in which participants will be randomized to consume either 57 grams of whole almonds daily or to consume an isocaloric cookie snack daily. Outcomes assessed will include blood and adipose immune markers, cardiometabolic biomarkers, and gut microbiome.
Eligibility
Inclusion Criteria:
- Body mass index (BMI): 30-45 kg/m^2
- Willingness to consume study foods
- Willing to comply with study protocol
- Consistent diet and activity patterns for 4 weeks
- Weight stable (no greater than 5 kg change over the last 3 months)
- Non-smoker > 1 year or more
Exclusion Criteria:
- Regular consumer of nuts
- Planning on getting viral vaccines during study
- Allergies to study foods (almonds, cookies)
- Illicit drug use
- Recent start of medications that affect metabolism or appetite
- Current use of medication that interfere with immune measures
- Diabetes
- Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
- Pregnant of lactating individuals
- Lidocaine allergies