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Higher vs. Lower Dose Heparin for PCI

Higher vs. Lower Dose Heparin for PCI

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

HD PCI is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (PCI).

Description

The primary objective of HD PCI is to compare the effect of a policy of higher dose heparin (100 U/kg) use to a policy of lower dose heparin (70 U/kg) use on death, myocardial infarction (MI) or target vessel revascularization (TVR) in patients undergoing elective percutaneous coronary intervention (PCI).

Eligibility

Inclusion Criteria:

  • Patients undergoing elective PCI

Exclusion Criteria:

  • Age <18 years
  • Planned chronic total occlusion PCI
  • Non-resident precluding follow up through local registries

Hospital (Cluster) Eligibility Criteria

Hospitals will be eligible to participate if they meet the following criteria:

  • Submit PCI procedure data to a compatible registry that is able to provide data for the trial
  • Site agrees to manage patients as per the higher or lower dose heparin policy in place during the given crossover period

Study details
    Cardiovascular Diseases
    Percutaneous Coronary Intervention

NCT04049591

Population Health Research Institute

13 August 2025

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