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Post-contracture Release Radiation for Dupuytren's Disease

Post-contracture Release Radiation for Dupuytren's Disease

Recruiting
18 years and older
All
Phase N/A

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Overview

To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.

Description

This is an observational, pilot study. Participants will be treated according to a standard treatment pathway, which includes contracture release treatment modalities such as limited fasciectomy, PNA and CCH injection, followed by post-operative radiation. All enrolled participants will undergo radiation treatment as soon as possible following contracture release. Radiotherapy will consist of 5 daily treatments of 300 cGy delivered to the palmar area followed by a 6-8 weeks break then a second 5 day course of radiation at 300 cGy, for a total of 3000 cGy in 10 total fractions. This dosing schedule is commonly used in the published literature. The data to be collected about participants, is their Southampton Dupuytren's score, history and clinical symptoms and photographs of their hand. This information will be obtained at baseline (pre-surgical intervention), at radiation treatment planning, approximately 6 weeks after completion of all radiation and at 1 and 2 years following completion of radiotherapy.

Eligibility

Inclusion Criteria:

  • Diagnoses of Dupuytren's disease
  • English-speaking

Exclusion Criteria:

  • Patients with Dupuytren's disease who are not currently seeking treatment

Study details
    Dupuytren's Disease
    Dupuytren Contracture
    Dupuytren Disease of Palm and Finger
    Dupuytren Disease of Finger
    Dupuytrens Contracture of Both Hands
    Dupuytren's Disease of Palm of Right Hand
    Dupuytren's Disease of Palm of Left Hand
    Dupuytren Contracture of Right Palm
    Dupuytren Contracture of Left Palm
    Dupuytren's Contracture Left
    Dupuytren's Contracture Right

NCT04122313

University of Minnesota

14 October 2025

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