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Reward and Drug Effects on Mood and Brain Response

Recruiting
18 - 25 years of age
Both
Phase N/A

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Overview

The goal of the study is to better understand the neural mechanisms underlying the rewarding, reinforcing properties of delta-9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, among healthy young adults.

Eligibility

Inclusion Criteria:

  • must be able to give informed consent
  • age 18-25 at the time of signing the consent form
  • fluency in English
  • body mass index of 19-26 (normal/overweight but not obese due to limitations of MRI)
  • negative urine drug screen (UDS) for all substances except THC (THC allowed)
  • must be medically and neurologically healthy
  • must not be taking psychoactive medications that would interfere with dronabinol and/or interpretation of fMRI data, including but not limited to the following classes of psychotropics: antidepressants, anxiolytics, sedative hypnotics, stimulants, antipsychotics, mood stabilizer
  • have used cannabis at least 10 times in their life, but report current and past lifetime cannabis use less than 7 days/week (daily)

Exclusion Criteria:

  • any current medical condition requiring psychoactive/psychotropic medication or medication that would interact with dronabinol, interpretation of fMRI data, and/or interfere with study procedures
  • current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (Dronabinol/Marijuana/Cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide.)
  • current Axis-I Diagnostic Statistical Manual-5 diagnosis (although mild and moderate Cannabis Use Disorder (CUD) and mild and moderate Alcohol Use Disorder (AUD) are allowed)
  • score >3 on the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) for individuals with current AUD
  • lifetime other lifetime Substance Use Disorder (although lifetime severe CUD and lifetime severe AUD are allowed)
  • currently seeking or engaged in CUD treatment or have desire to cut down or stop cannabis use.
  • in recovery or enrolled in treatment for any substance (including cannabis and alcohol)
  • lifetime psychosis, mania, Attention-Deficit/Hyperactivity Disorder, Obsessive-Compulsive disorder, Feeding and Eating disorder, or Post-Traumatic Stress Disorder
  • score >7 on the Hamilton Depression Rating Scale or score >7 on the Hamilton Anxiety Rating Scale
  • less than a high school education
  • lack of fluency in English
  • night shift work
  • currently pregnant confirmed by urine pregnancy test or planning pregnancy or lactating (women)
  • unwilling/unable to sign informed consent document
  • inability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report
  • left-handed
  • presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)
  • positive UDS for any drug except THC
  • positive breathalyzer for acute alcohol intoxication
  • heavy alcohol use (>4 days week) in the past month
  • heavy nicotine use (>20 cigarettes per week) in the past month

Study details

Cannabis Use, Healthy

NCT04512365

University of Illinois at Chicago

15 May 2024

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