Overview
This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.
Description
Weight gain often occurs following a liver transplant. This weight gain is problematic as it leads to many other health problems. The reasons of this weight gain are still poorly understood. To better understand weight gain, this study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on heart and blood vessel health.
This study will help researchers to better understand weight gain after a transplant. This knowledge will help doctors prevent weight gain after a liver transplant and therefore improve the health of liver transplant patients.
Eligibility
Inclusion Criteria:
- Age > 18 years
- At least 12 months after LT
- Obese (BMI > 30kg/m2)
Exclusion Criteria:
- Acute cellular or chronic rejection within 3 months
- Post-LT liver or non-liver related malignancy
- Active viral hepatitis (B or C), autoimmune hepatitis
- Untreated biliary strictures or vascular complications (i.e. hepatic artery thrombosis)
- Poorly controlled Diabetes mellitus
- Relapse of alcohol abuse after LT
- Stage 5 Chronic Kidney Disease
- Current pregnancy