Overview
This is an observational study for patients with prostate cancer that will be treated with Androgen Deprivation Therapy. The study will help the investigators learn more about how these medications affect the heart and how those effects relate to patients' medical history and social determinants of health (such as race, gender identity, education, occupation, access to health services and economic resources). Patients on this study will have echocardiograms, blood draws, and answer questions about their symptoms and activity level. Patients will be followed on this study for up to 5 years.
Description
The investigators propose a prospective longitudinal cohort of prostate cancer patients treated with Androgen Deprivation Therapy (ADT) to determine the associations between social determinants of health (SDOH) and cardiotoxicity risk and to determine wither associations between SDOH and cardiotoxicity risk differs according to race. Patients will be followed with serial echo, blood draw, and surveys prior to start of ADT and then 6 months, 1 year, 2 years, 3 years, and 5 years after start of ADT.
Eligibility
Inclusion Criteria:
Men older than 18 years of age Prostate cancer diagnosis planned for treatment with ≥6
months of ADT (with or without RT) for clinically localized, biochemically recurrent, or
oligometastatic disease. Planned ADT regimens may include: GnRH agonists (goserelin,
histrelin, leuprolide, triptorelin) with or without first-generation anti-androgens and
GnRH antagonists (degarelix). Additional systemic agents, including second-generation
androgen receptor signaling inhibitors, may be used in combination with GnRH
agonist/antagonist therapies per provider clinical discretion.
Ability to provide informed consent
Exclusion Criteria:
Prior ADT injection within 6 months prior to enrollment Inability or unwillingness to
provide consent