Overview
This study will compare the accuracy of a real-time Cine sequence in assessing cardiac volumetry.
Description
This is a single-centre prospective study involving up to 570 patients with known or suspected cardiac disease referred for routine clinical cardiovascular magnetic resonance (CMR) assessment at Glenfield General Hospital, Leicester. In addition to standard multi-breath-hold steady-state free precession (SSFP) imaging (undertaken as part of the routine scan), each patient will also undergo additional imaging with a non-breath-hold multi-slice real-time cine sequence.
The primary outcome is the assessment of cardiac volumetry and function (end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass) as measured by (1) the standard multi-breath-hold SSFP technique and (2) the non-breath-hold multi-slice real-time cine sequence. Secondary outcome measures will be (1) the time required for each scan, and (2) image quality for each scan. An additional secondary outcome will be to compare indexed cardiac volumes with those indexed according to measured body-surface area.
Eligibility
Inclusion Criteria:
- Patients aged ≥ 18 years
- Referred for routine CMR imaging
- Willing and able to give informed consent
- Willing and able to comply with the requirements of the study
- Able to understand written English
Exclusion Criteria:
- Severe claustrophobia
- Absolute contraindications to CMR (those with CMR conditional or safe devices will be eligible for inclusion)
- Unable to provide informed consent
- Participants unable to understand written English