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Pencil Beam Proton Therapy for Pelvic Recurrences in Rectal Cancer Patients Previously Treated With Radiotherapy

Recruiting
18 years of age
Both
Phase 2
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Overview

Study design:

A prospective phase II, non-randomized observational study of dose-escalated pencil beam proton therapy re-irradiation for pelvic recurrences from rectal cancer.

Re-irradiation is either a part of neo-adjuvant treatment or as a definitive treatment strategy for un-resectable recurrences.

Eligibility

Inclusion Criteria:

  • • Locally recurrent rectal cancer.
    • Bioptically verified (adenocarcinoma )
    • Available dose plan from primary radiotherapy
    • Previous pelvic RT (>30Gy EQD2)
    • Evaluated in MDT-conferences (Herlev, Aarhus)
    • Age>18 years
    • PS 0-2
    • Adequate organ function
    • Informed consent

Exclusion Criteria:

  • Non-resectable distant metastases (PET-CT)
  • Unable to undergo MRI, PET-CT
  • Inability to attend full course radiotherapy and follow up in the out patient clinic.

Study details

Rectal Cancer Recurrent

NCT04695782

University of Aarhus

25 January 2024

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