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tDCS and Metacognitive Strategy Training in Stroke

Recruiting
18 - 85 years of age
Both
Phase N/A

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Overview

Specific Aim 1: Complete pilot testing of study protocol in individuals with chronic stroke for feasibility evaluation and protocol refinement. Specific Aim 2: Estimate the preliminary effect of CO-OP+tDCS on activity performance in individuals with chronic stroke.

Description

A number of daily life activities are discontinued after stroke. These discontinued activities typically include basic self-care, instrumental activities of daily living, leisure, and work. These changes in participation contribute to decreased quality of life and life satisfaction. The Cognitive Orientation to daily Occupational Performance (CO-OP) approach is a behavioral problem-solving intervention that focuses on teaching clients how to apply cognitive strategies to enhance learning and overcome activity performance barriers.

CO-OP uses meaningful, client-chosen activities to drive new skill learning and neural reorganization. Consistent with these principles of neuroplasticity, transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method of modulating cortical excitability through application of low currents to targeted regions on the scalp.

There are known positive effects of CO-OP to improve activity performance and for tDCS to improve impairment level outcomes post-stroke. The investigators hypothesize that the known effects of CO-OP may be amplified with use of tDCS to alter known neural hubs of executive networks that support problem-solving. In sum, (1) CO-OP is effective at improving activity performance, and (2) the effects of CO-OP may be amplified through novel methods that allow for placing the brain in an enhanced neuroplastic state, such as tDCS.

Eligibility

Inclusion Criteria:

  • >6 months post-ischemic stroke
  • not currently receiving therapy services
  • a minimum of four self-identified functional goals

Exclusion Criteria:

  • severe depressive symptoms (>20 on Patient Health Questionnaire)
  • dementia symptoms (<24 on Montreal Cognitive Assessment)
  • any additional neurological disorders
  • moderate-severe aphasia (NIH Stroke Scale aphasia scale of greater than or equal to 2)
  • any tDCS contraindication

Study details

Chronic Stroke

NCT05248178

University of Missouri-Columbia

15 May 2024

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