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Care Plans for Cancer Predisposition

Recruiting
12 years of age
Both
Phase N/A

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Overview

Develop and evaluate acceptability, feasibility, and preliminary efficacy of digital care plan and accompanying text message reminders for children and adolescents with a known Cancer Predisposition Syndromes (CPS).

Description

As over 15% of pediatric cancers are associated with a cancer predisposition, it is increasingly becoming standard of care for children with cancer, as well as those with suspected hereditary risk, to be evaluated for germline cancer predisposition. Unfortunately, the increase in pediatric genetic testing has exceeded the pace of research supporting effective cancer surveillance in positive cases. Additionally, guidelines for cancer predisposition management are not easily accessed or understood by families; thus, there is often a disconnect between the understanding and retention of such information relayed to families.

In this study, Investigators will develop and evaluate the acceptability, feasibility, and preliminary efficacy of digital care plans for Cancer Predisposition Syndromes (CPS) with accompanying text message reminders for children and adolescents with a known CPS. Digital care plans and text messages will be created for 10 common CPS. Investigators will use a quasi-experimental design with pre and post testing of the same cohort, before and after delivery of care plan and accompanying messages. To evaluate the impact of the digital care plans, Investigators will compare assessments of the same cohorts at 3 and 6 months time points.

Eligibility

Inclusion Criteria:

Parents

  1. Parent or Legal Guardian of a patient with a known cancer predisposition syndrome diagnosed within the last 5 years
  2. Received care at the Cancer Predisposition clinic at the Children's Hospital of Philadelphia (CHOP), or other medical institutions (does not need to be receiving follow-up care at CHOP)
  3. Appropriate to approach per oncology team/cancer predisposition team
  4. No cognitive impairment limiting ability to complete measures
  5. Ability to read and speak English fluently

Adolescent/Young Adult (AYA) probands

  1. Child proband with a known cancer predisposition syndrome diagnosed within the last 5 years
  2. Ages 12+
  3. Received care at the Cancer Predisposition clinic at the Children's Hospital of Philadelphia (CHOP), or other medical institutions (does not need to be receiving follow-up care at CHOP)
  4. Appropriate to approach per oncology team/cancer predisposition team
  5. No cognitive impairment limiting ability to complete measures
  6. Ability to read and speak English fluently

Exclusion Criteria:

  • Not meeting any of inclusion criteria

Study details

Genetic Predisposition

NCT05736497

Children's Hospital of Philadelphia

25 January 2024

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