Overview
Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome
Description
Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel syndrome: Does this add to current treatment?
Eligibility
Inclusion Criteria:
- • Age ≥ 18 years,
- Man and Women, Negative pregnancy test and effective contraception,
- IBS defined by the Rome criteria IV
- During the previous seven days the inclusion visit, average numeric rating scale (NRS) pain ≥ 4.
- IBS Treatment stable for 1 month
Exclusion Criteria:
- • Breastfeeding
- Diabetic patients
- Significant liver function abnormalities (transaminases> 3N, cholestasis) and moderate renal disease (MDRD <60 ml / min)
- Addiction to alcohol and / or drugs,
- Antiepileptic drugs taken (epilepsy or chronic pain)
- Chronic pain of greater intensity than that related to IBS,
- Known Allergyto succinimides (ethosuximide, methsuximide, phensuximide) and pentoxifylline.
- History or current severe depression (hospitalization, long-term antidepressant treatment)
- Psychotic disorders,