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Interventions in Mathematics and Cognitive Skills

Interventions in Mathematics and Cognitive Skills

Recruiting
6-12 years
All
Phase N/A

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Overview

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

Description

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

To achieve this goal, investigators will use a theoretically-motivated integrated symbolic/non-symbolic (iSNS) intervention with a randomized controlled design to enhance cross-format mapping between symbolic and nonsymbolic representations of quantities. The investigators will develop innovative computational models to investigate individual differences in latent cognitive processes and brain plasticity that contribute to learning, long-term retention, and transfer in children.

The investigators will assess performance in several areas and investigate cognitive and neural mechanisms that support numerical skill acquisition in children with differing levels of math learning abilities.

Eligibility

Inclusion Criteria:

  1. Elementary school aged children starting from first grade (6-12 years old)
  2. IQ: Participants with a Full Scale IQ > 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
  3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
  4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
  5. Normal or corrected-to-normal vision and no hearing impairments
  6. Inclusion in MRI scan session: Right-handed

Exclusion Criteria:

  1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
  2. History of trauma involving head injury
  3. Consistent psychiatric medications
  4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)

Study details
    Math Learning Disability
    Child Development
    Developmental Disability
    Learning Disabilities
    Learning Disabled
    Learning Curve
    Mathematics Disorder
    Dyscalculia
    Dyscalculia
    Primary
    Dyscalculia
    Acquired
    Specific Learning Disorder
    With Impairment in Mathematics
    Individuality
    Behavior
    Child
    Behavior and Behavior Mechanisms
    Behavior
    Decision Making
    Neuronal Plasticity
    Cognition
    Cognition Disorder
    Cognitive Dysfunction
    Cognitive Change
    Cognitive Impairment
    Mild
    Cognitive Developmental Delay
    Cognitive Orientation
    Cognitive Delay
    Mild
    Cognitive Deficits
    Mild
    Cognitive Abnormality
    Neuroscience

NCT05201534

Stanford University

19 August 2025

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