Overview
The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease.
Observational study case-only
Description
Objectives
- how many patients will experience motor or nonmotor fluctuation during follow-up period?
- in how many patients, does motor fluctuation precede nonmotor fluctuation?
- in how many patients, does nonmotor fluctuation precede motor fluctuation?
Participants: persons with Parkinson disease in early stage who does not have motor or nonmotor fluctuation
Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for each participants
Eligibility
Inclusion Criteria:
- clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society Brain Bank criteria
- early stage
Exclusion Criteria:
- dementia (MMSE<26)
- persons who refuse participating