Overview
Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.
Eligibility
Inclusion Criteria:
- Personal or familial cognitive complaints
- Individual aged ≥ 65 years old and < 81 years old
- Instrumental activities of daily living (IADL) score between 3-4
- French speaking individual
- Informed consent signed For PLHIV
- HIV infection
- Undetectable HIV viral load ≥ 1 year
- Current cluster of differentiation (CD4) cell count > 100/mm3 For controls
- negative HIV serology ≤ 6 months
Exclusion Criteria:
- Opportunistic infection < 5 years
- Contraindications to MRI