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Yellow Fever Human Infection Model With YF-17D

Yellow Fever Human Infection Model With YF-17D

Non Recruiting
18-50 years
All
Phase N/A

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Overview

No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.

Description

No antiviral treatment exists for yellow fever, only supportive care, and therefore we rely on prevention through vaccination. Although this vaccine is very effective, stockpiles are insufficient in outbreak situations and some people have a contraindication to be vaccinated. For those who are unprotected and at risk of yellow fever infection, treatment could be life saving.

Eligibility

Inclusion Criteria:

  • age 18-50 years

Exclusion Criteria:

  • contraindication to receive YF-17D (immune deficiency, thymus illness)
  • previous YF vaccination
  • pregnancy
  • chicken egg allergy
  • hypersensitivity to any other substance in the YF-17D vaccine
  • interval of < 4 weeks of another live attenuated vaccine

Study details
    Yellow Fever

NCT05901454

Leiden University Medical Center

20 August 2025

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