Overview

This study aims to evaluate the use of a prostate cancer specific predisposition genetic panel test in men with / at high risk of prostate cancer. The genetic test will analyse men's DNA samples for the presence of mutations in rare genes as well as common genetic variation to provide men with information about their risk of prostate cancer. This study will evaluate the clinical impact of the test on risk assessment and clinical management in terms of screening and treatment.

Eligibility

Inclusion Criteria:

Affected cohort:

1. Affected with PrCa < 70 years or
2. Affected with metastatic castration resistant PrCa (mCRPC) at any age or
3. Affected with PrCa and a family history defined as
   1. two or more cases in family with one case < 70
   2. three or more cases any age (FDR or SDR)

Unaffected cohort:

Aged >30 and with a family history defined as:

1. FDR diagnosed < 70
2. 2 or more cases in First or Second Degree Relatives (FDR/SDR) with one case diagnosed < 70 years
3. 3 or more cases at any age (on same side of family)

Exclusion Criteria:

• • WHO performance status 4