Overview
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Eligibility
Inclusion Criteria:
• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)
- Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
- Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
- Age at least 18
- Able to participate in intraoperative testing
- English speaking
Exclusion Criteria:
- Age less than 18
- Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)