PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial

Overview

This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP strategy.

Eligibility

Inclusion Criteria:

        Intubated, mechanically ventilated patients with diagnosis of ARDS according to ARDS Berlin
        standard by attending doctor
        Exclusion Criteria:
          1. Age < 18 years old and > 90 years old;
          2. Pregnancy;
          3. EIT contradictions (presence of pacemaker or automatic implantable cardioverter
             defibrillator);
          4. Severe intracranial hypertension;
          5. Pneumothorax, pneumomediastinum, subcutaneous emphysema or at high-risk for
             pneumothorax (e.g., pneumatocele, interstitial lung disease);
          6. Unstable hemodynamic status intorerable to lung recruitment and PEEP titration, judged
             by an attending intensivist; (This may be a transient criterion, since patients
             meeting this criterion might be included later if hemodynamics improves)
          7. End status of disease;
          8. Patients or their families refused to participate in the study