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Comparison of Outcomes Between Low Dose Emicizumab and Factor VIII in Clinically Severe Hemophilia A

Comparison of Outcomes Between Low Dose Emicizumab and Factor VIII in Clinically Severe Hemophilia A

Recruiting
3-30 years
Male
Phase 2/3
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

  • To outcome between low dose Emicizumab and low dose prophylaxis with FVIII concentration
    • To study pharmacokinetic, side effect of low dose Emicizumab

Description

  • To compare outcome between low dose Emicizumab and low dose prophylaxis with FVIII concentration using ABR, AJBR and HJHS, HaemoQoL
    • To study pharmacokinetic, side effect and effectiveness of low dose Emicizumab

Eligibility

Inclusion Criteria:

  • Severe or moderate Hemophilia A with baseline FVIII:C of <3 IU/dl or severe bleeding phenotype
  • Receiving low dose FVIII prophylaxis for at least 6 months

Exclusion Criteria:

  • Detectable FVIII inhibitor at screening
  • Detectable FVIII inhibitor at screening Having other underlying diseases: Juvenile rheumatoid arthritis, metabolic bone diseases, or other conditions mimicking or causing joint diseases

Study details
    Severe Hemophilia A Without Inhibitor
    Joint Bleed

NCT06155955

Chulalongkorn University

7 March 2024

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