Overview
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm. The investigators will daily (for a maximum of 8 days) measure esophageal pressures with a balloon catheter to quantify inspiratory effort and respiratory muscle function, and perform daily ultrasound measurements of the diaphragm and the lungs. The investigators hypothesize that a small inspiratory effort will result in the preservation of diaphragm function and have no adverse effect on lung function.
Eligibility
Inclusion Criteria:
- age > 28 days
- weight > 3kg
- requiring invasive mechanical ventilation
- anticipated length of ventilation > 48h
Exclusion Criteria:
- refusal of consent
- mechanical ventilation ≤ 2 weeks before inclusion
- known anatomical malformation of the diaphragm (including congenital diaphragmatic hernia)
- contra-indication to the placement of a naso-gastric esophageal balloon catheter