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Developing an Opioid Taper Intervention Before Total Joint Arthroplasty

Recruiting
18 years of age
Both
Phase N/A

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Overview

The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery. The main questions it aims to answer are:

  • Is the intervention feasible and acceptable to patients?
  • Does the intervention result in a decrease in opioid dose during the preoperative period?

Participants will meet with a clinical pharmacist, who will provide some basic education on pain and opioids, and will propose an opioid taper schedule. The pharmacist will then follow-up with the participant by phone each week until surgery to assess progress and adjust the taper as necessary.

Eligibility

Inclusion Criteria:

  • decided to pursue primary, unilateral total knee or hip arthroplasty with planned surgery date in 4-8 weeks
  • currently taking between 20 and 90 MME of oral opioids, and that dose has been stable for at least 3 months
  • have a reliable telephone number for contact
  • speaks English

Exclusion Criteria:

  • Taking opioid medications that include:
    • Buprenorphine
    • Methadone
    • Long-acting formulations of opioid pain medications (e.g., extended-release oxycodone and extended-release morphine)
    • Transdermal formations of opioid pain medications (e.g., fentanyl patches)

Study details

Arthritis Knee, Arthritis Hip, Chronic Pain

NCT05788016

University of Alabama at Birmingham

9 June 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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