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Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker

Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker

Recruiting
18 years and older
Female
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This project investigates circulating tumor DNA (ctDNA) in patients with suspected ovarian malignancy.

We hypothesize that measurement of ctDNA in women with suspected ovarian cancer can improve the diagnostic efficiency for preoperative differentiation between benign and malignant masses.

Specifically, we hope to determine the diagnostic efficiency of ctDNA alone and ctDNA in combination with imaging modalities (ultrasonography, MRI, PET-CT) and CA 125 for preoperative differentiation between benign and malignant adnexal masses. Based on this, we hope to develop an improved diagnostic algorithm.

The mutational profile and relation to tumour type, stage, treatment response and prognosis will be explored.

Analyses of blood and tissue samples will be used to examine the disease development and biology.

Blood samples, tumour tissue and data on imaging modalities as well as CA 125 will be collected prospectively in consecutive women referred to Aarhus University Hospital.

Eligibility

Inclusion Criteria:

  • Suspected ovarian neoplasm
  • Informed consent

Exclusion Criteria:

  • Inability to give informed consent
  • Previous ovarian cancer diagnosis

Study details
    Ovarian Neoplasms
    Ovary Cancer
    Ovarian Cysts

NCT05763511

University of Aarhus

14 May 2024

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