Overview
Explore with active cancer patients with acute ischemic stroke in the human body characteristic microorganism disorder to clinical prognosis of the predictive value of the secondary objective: to observe with active cancer patients with acute ischemic stroke in the body of microorganisms and their serological indexes change law of exploration condition change related biomarkers of microscopic objects group based on the human body.
Description
investigators recently found that changes in gut microbiota in patients with ischemic stroke are associated with the development of disease. However, there are few studies on the correlation between ischemic stroke with cancer and human microbiome and metabolites Whether the human microbiome and its metabolites are associated with the prognosis of such patients remains to be investigated. Therefore, this study hypothesized that structural changes in the human microbiome and its metabolites in patients with acute ischemic stroke with active cancer were associated with stroke severity and disease recovery Therefore, this topic proposed by collecting active follow-up cancer of acute ischemic stroke patients after admission and oral swabs Excrement and urine and blood samples, and based on the queue, follow-up analysis of the human microbiome dynamic change rule and the prognosis of patients with cancer of the acute ischemic stroke correlation, activity, further explore the secondary prevention of stroke management strategy based on the human microbiome.
Eligibility
Inclusion Criteria:
- 1: It meets the diagnostic criteria for acute ischemic stroke 2: Age ≥ 18 years 3: The onset time is less than or equal to 2 weeks 4: Diagnosis of cancer before stroke onset or during hospitalization and active cancer (failure to meet clinical criteria for cure, or discovery of recurrence or metastasis) 5: Sign an informed consent form, provide relevant medical history information and provide biological specimens
Exclusion Criteria:
- 1: Previous history of disabling stroke (pre-onset mRS ≥2) 2: Primary central nervous system tumor or hematologic system tumor 3: The cancer meets the criteria for clinical cure and has not recurred or metastasized for more than 5 years 4: Antibiotics, prebiotics/probiotics taken within 1 month 5: Patients who cannot have stool specimens within 4 days of admission