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CBD-Microglia PET Study

Recruiting
18 - 55 years of age
Both
Phase N/A
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Overview

This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.

Description

This study aims to examine the effect of cannabidiol (CBD), pre-treatment, as Epidiolex, on brain microglial activation in healthy human subjects using [11C]PBR28 PET imaging. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects. Lastly, this research study will also examine the relationship between brain microglial activation and central pain sensitization with CBD pre-treatment.

Eligibility

Inclusion Criteria:

  1. Men and women aged 18- 55 years
  2. No significant medical or neurological illness
  3. No implanted metal devices that may pose a risk during MRI scanning
  4. Within the annual permissible radiation exposure
  5. Able to provide written informed consent.

Exclusion Criteria:

  1. Current use of any medications
  2. Presence of metal in the body
  3. Pregnancy or lactation

Study details

CBD, Healthy

NCT04398719

Yale University

25 January 2024

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