Overview
The goal of this observational study is to learn about relation between vitamin D levels in subjects with head and neck cancer. The main question it aims to answer are:
- variation of vitamin D levels in the study population at different time points
- relation between therapy side effects and vitamin D level
- relation between disease outcome and vitamin D level Participants will be followed as per clinical practice
Description
There are only a few works in the literature that correlate the circulating levels of vitamin D with the prognosis or development of toxicity in treated HNSCC patients with radical intent radiation therapy. These small studies have highlighted a worse outcome and greater toxicity in patients with low vitamin D levels. The study aims to study the variations in circulating levels of vitamin D in a multicenter cohort of patients with HSNCC prospectively collected and to evaluate the impact of vitamin D levels at diagnosis on the development of toxicity and on disease outcome
Eligibility
Inclusion Criteria:
histologically proven HNSCC (squamous cell carcinomas), all subsites
- non-metastatic locally advanced stages
- patients candidate for radical or adjuvant radiotherapy
- patients candidate for bilateral neck irradiation
- written informed consent
Exclusion Criteria:
- distant metastases
- patients with known disorders of calcium/vitamin D metabolism