Overview
In the course of a scientific accompanying program, the project pursues the goal of gaining further insight into a possible connection between various influencing factors and the development of postoperative delirium. Against this background, in addition to the primary goal of exploring delirium rates, we aim to identify associations between other secondary end goals like the internal circadian time or the heart rate variability and the occurrence of postoperative delirium. For this purpose, patients of the QC-POD (NCT04355195) sample will be studied.
Description
The project aims to improve the understanding of the internal circadian time (chronotype) and other sleep parameters, as well as further secondary end goals, in relation to the development of postoperative delirium. In the course of this the project would like to investigate the perioperative heart rate variability. Also, the association of perioperative peripheral cholinesterase activity with perioperative heart rate variability and the development of POD will be explored. Additionally, the investigator will analyze the correlation of intraoperative EEG signatures with perioperative heart rate variability, and explore any association of core body temperature and the development of postoperative Delirium.
Eligibility
Inclusion Criteria:
- Age ≥ 70 years
- Male and female patients
- Patients who have been included in QC-POD
- Eligible patients* for inclusion: informed consent by the patient, preoperatively with verbal and written informed consent before the start of data collection
- Incapacitated patients for inclusion: Written informed consent by a legal representative
- surgery (elective and not elective)
Exclusion Criteria:
- Moribund patients (palliative situation)
- Insufficient knowledge of the German language
- Cardiac arrhythmia (e.g. atrial fibrillation)
- Presence of a pacemaker
- Condition after heart transplantation
- Inflammation in the area of the frontal sinus