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Screening for BCRL in Targeted Therapy for Breast Cancer

Screening for BCRL in Targeted Therapy for Breast Cancer

Non Recruiting
18-80 years
Female
Phase N/A

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Overview

This a prospective, longitudinal study designed to track edema and Breast Cancer Related Lymphedema (BCRL) onset in breast cancer patients taking targeted therapy treatments for early and metastatic breast cancer.

A Perometer and Sozo devise will be used to measure volume changes

Description

This study will compare patients' relative arm volume changes and symptoms data from before drug therapy throughout drug treatment and for up to six months after treatment has finished.

A Perometer and Sozo device will be used to measure volume changes

All participants will be accrued at Massachusetts General Hospital for a target accrual of 166 participants.

Eligibility

Inclusion Criteria:

  • Subjects who are receiving treatment in the MGH Breast Cancer Center who are enrolled in a DF/HCC-regulated targeted therapy trial for the treatment of early or metastatic breast cancer or patients being treated with a targeted therapy that may alter their risk of developing edema or BCRL will be eligible.
  • Subjects that will be eligible for the study include:
  • Females between 18 and 80 years of age
  • With a history of breast cancer
  • 4 weeks or more post-surgery
  • With or without edema
  • Undergoing treatment with targeted therapy for early or metastatic disease.

Exclusion Criteria:

  • Patients who cannot attain 90 degrees of shoulder abduction (position of measurement with Perometer).

Study details
    Lymphedema
    Lymphedema Arm
    Lymphedema of Upper Arm
    Lymphedema of Upper Limb
    Lymphedema of the Hands
    Edema
    Edema Arm
    Breast Cancer Lymphedema
    Breast Cancer Metastatic
    Breast Cancer Stage
    Breast Cancer

NCT05142800

Massachusetts General Hospital

20 August 2025

FAQs

Learn more about clinical trials

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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