Biological Bank for Atrial Fibrillation and Stroke

Overview

Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years.

According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted.

The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.

Eligibility

Group 1a:

• Inclusion Criteria :
  • Atrial Fibrillation history
• Exclusion Criteria :
  • No Atrial Fibrillation history
  • patient who didn't signed consent

Group 1b

• Inclusion Criteria :
  • Atrial Fibrillation history
  • Scheduled electrophysiological exploration or Atrial Fibrillation ablation
• Exclusion Criteria :
  • No Atrial Fibrillation history
  • pregnant women
  • patient who didn't signed consent

Group 1c

• Inclusion Criteria :
  • Atrial Fibrillation history
  • Stroke history
• Exclusion Criteria :
  • patient who didn't signed consent

Group 2

• Inclusion Criteria :
  • patient over 80
  • Electrocardiography : sinusal rhythm
  • Transthoracic echocardiogram : no left atrial dilatation
• Exclusion Criteria :
  • atrial fibrillation history
  • Transthoracic echocardiogram : Left atria >25cm², > 34m/m2), LVEF (left ventricular ejection fraction) < 50%
  • Electrocardiography : QRS > 90 ms
  • cardiac pathologies (excepted hypertension and valvulopathies)
  • History of stroke and transient ischemic attack
  • patient who didn't signed consent

Group 3

• Inclusion Criteria :
  • cryptogenic stroke history before 50 yo
  • No Atrial Fibrillation history
• Exclusion Criteria :
  • Atrial Fibrillation history
  • stroke over 50 yo
  • patient who didn't signed consent