Overview
This is a randomized controlled clinical trial designed to evaluate the therapeutic effects of Montelukast in patients diagnosed with Acute Myocardial Infarction (AMI). The study aims to investigate whether the administration of Montelukast influences inflammatory markers and the extent of cardiac injury following a heart attack.Participants will be randomly assigned to receive either the active medication or a placebo to provide high-quality evidence regarding the drug's potential cardioprotective and anti-inflammatory properties. The trial is conducted through the Faculty of Pharmacy and Faculty of Medicine at Mansoura University
Eligibility
Inclusion Criteria:
- Age 30-75 years Diagnosed with STEMI within 6 hours of symptom onset Undergoing PCI or thrombolysis Eligible for standard ACS therapy signed Informed consent
Exclusion Criteria:
- Chronic use of anti-inflammatory drugs
- Severe hepatic or renal impairment
- Hypersensitivity to Montelukast
- Autoimmune or inflammatory diseases
- Cardiogenic shock, severe heart failure or structural complications such as papillary muscle rupture
- Having received cardiopulmonary resuscitation
- Severe and inadequately controlled hypertension
- History of myocardial infarction
- Concomitant active bleeding or visceral hemorrhage
- Concomitant malignant tumors, lymphomas, leukemias, or other diseases
- gastrointestinal surgery within the past 4 weeks that may affect the absorption of the investigational drug
- Family history of psychiatric disorders
- Pregnancy or lactation
- Participation in another clinical trial