Overview
This will be a randomized clinical trial examining the efficacy and safety of ARAT (intervention group) in patients with chronic GERD symptoms (typical symptoms of GERD, i.e. heartburn or acid reflux/regurgitation at least twice a week) for the last 6 months.
Patients must have a positive pH test and a negative manometry (no treatment) procedure.
Eligibility
Inclusion Criteria:
- Chronic GERD symptoms (at least 1 typical symptom of GERD, i.e. heartburn or acid reflux/regurgitation at least twice a week) for last 6 months
- Objective evidence of reflux disease (positive ambulatory pH study.)
Exclusion Criteria:
- Patients unable to or unwilling to participate or consent.
- Age <18 years or >80 years.
- Allergic or intolerant to PPI medications.
- Large hiatal hernia > 3 cm and Hill grade IV.
- Barrett's esophagus.
- Esophageal stricture with any prior intervention.
- Major motility disorder.
- Eosinophilic esophagitis.
- Gastroparesis documented by abnormal gastric emptying time.
- Previous fundoplication, myotomy or LINX surgery.
- Cirrhosis with esophageal and/or gastric varices.