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Establishment of NAFLD Cohort and Development of Fibrosis Markers

Establishment of NAFLD Cohort and Development of Fibrosis Markers

Recruiting
18 years and older
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

This study is designed for establishment of non-alcoholic fatty liver disease patients cohort to development of markers to predict histologic progression of liver fibrosis.

Description

  • Acoustic radiation force impulse elastography and transient elastography
    • Liver tissue (frozen tissue, paraffin block)
    • Whole blood, Serum
    • Fat amount ratio CT (Visceral adipose tissue, Subcutaneous adipose tissue amount)
    • Body composition analyzer (InBody scale):Total fat/muscle mass and appendicular skeletal muscle mass
    • Pulmonary function test with post-bronchodilator response and DLCo
    • EKG, EchoCG, Heart CT (Coronary calcium score), and Pusle wave velocity (AI index, arterial stiffness)
    • Brain MRI or CT
    • Upper esophagogastroscopy and colonoscopy
    • Berlin score questionnaire and Polysomnography

Eligibility

Inclusion Criteria:

  • Patients with histologically confirmed fatty liver disease
  • Patients with radiologically confirmed fatty liver disease

Exclusion Criteria:

  • History of significant alcohol consumption
  • Viral hepatitis
  • Autoimmune hepatitis
  • Metabolic diseases (e.g. hemochromatosis, M. Wilson, alpha 1-antitrypsin deficiency)
  • Hepatotoxic medication (e.g. amiodarone)

Study details
    Fibrosis of Liver

NCT02206841

Seoul National University Boramae Hospital

25 May 2025

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