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Nutritional Deficiency and Recurrent Miscarriage

Recruiting
18 - 40 years of age
Female
Phase N/A

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Overview

This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.

Description

Recurrent miscarriage is affecting around 5% women at reproductive age. And the underlying causes remain undetermined in 50%-70% of cases. Although animal models and linkage analysis according to family studies have identified that niacin deficiency can lead to congenital malformations and recurrent miscarriage. Evidence based on population is lacking with regard to the effect of blood niacin levels on recurrent miscarriage. We intend to enroll 499 pregnant women confirmed by a positive blood human chorionic gonadotropin test and with history of unexplained recurrent miscarriage. By testing their blood niacin levels and following up to the end of first-trimester pregnancy, this study aims to examine the role of niacin levels in preventing miscarriages among women with history of recurrent miscarriage.

Eligibility

Inclusion Criteria:

  • 18-40years old, female
  • Positive blood human chorionic gonadotropin test
  • Naturally pregnant
  • History of recurrent miscarriage (2 or more consecutive spontaneous miscarriage within 28 weeks of gestation)
  • Willing to participate in this study with informed consent

Exclusion Criteria:

  • Women whose confirmed cause of recurrent miscarriage has nothing to do with nutritional deficiencies, including chromosomal abnormalities, abnormal uterine anatomy, immune system diseases, blood diseases, etc.
  • Women with Hepatitis B, syphilis, HIV/AIDS and other infectious diseases.
  • Women with serious conditions, such as schizophrenia, tumors, heart failure

Study details

Recurrent Miscarriage

NCT05267678

Westlake University

25 January 2024

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