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Post-authorization Safety Study of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Treated With Mogamulizumab

Recruiting
18 years of age
Both
Phase N/A

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Overview

This is a non-interventional cohort study evaluating non-relapse mortality and toxicities in patients with CTCL or ATLL treated with mogamulizumab pre- or post- alloHCT for patients transplanted beginning January 1, 2012 until accrual is complete.

Description

This is an observational, retrospective and prospective study where subjects who have received mogamulizumab either within one year before or within 18 months after transplantation will be followed for data collection. Data will be collected at baseline (retrospectively), 100 days post alloHCT, 6-months, 1 year and at 2 years post alloHCT (retrospectively and prospectively).

A cut-off time limit of 18 months post alloHCT exposure will allow at least 6 months of follow-up within the 2 years post-alloHCT follow-up period.

Eligibility

Inclusion Criteria:

  • Patients registered to the Center for International Blood and Marrow Transplant Research (CIBMTR)
  • Adults ≥18 years of age with either CTCL or ATLL;
  • AlloHCT performed from January 2012 onward.

Exclusion Criteria:

• Patients without consent for research.

Study details

Leukemia/Lymphoma, Cutaneous T Cell Lymphoma, ATLL

NCT04014374

Kyowa Kirin, Inc.

14 February 2024

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