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Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence

Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence

Recruiting
18-80 years
Female
Phase N/A
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Overview

This is a prospective study to investigate the potential efficacy of 68Ga-FAPI PET/CT for recurrence detection of epithelial ovarian cancer in comparison with 18F-FDG PET/CT.

Description

Gallium 68-labeled fibroblast-activation protein inhibitor (68Ga-FAPI) has recently been a potential radiotracer for gynecological malignancies,including ovarian cancer. Early detection and localization of sites of recurrence helps to identify ovarian cancer patients who will benefit the most from secondary surgery, chemotherapy, or radiation therapy. Its clinical utility for recurrence detection of epithelial ovarian cancer and histological validation of FAPI findings is not well established.

Eligibility

Inclusion Criteria:

  • adult patients (age>18 and<80 years)
  • patients with clinically suspected recurrent ovarian cancer
  • patients who underwent paired 18F-FDG and 68Ga-FAPI PET/CT for the most proper treatment strategy within 1 week
  • patients who did not receive any other treatment 4 weeks before PET imaging

Exclusion Criteria:

  • pregnant patients
  • patients with poor performance status
  • patients unwilling to provide written informed consent

Study details
    68Ga-FAPI
    Ovarian Cancer
    Epithelial Ovarian Cancer
    Positron Emission Tomography

NCT05856409

RenJi Hospital

25 January 2024

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