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Cognitive Bias Modification for OCD

Cognitive Bias Modification for OCD

Non Recruiting
18 years and older
All
Phase N/A

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Overview

This study will conduct the development and preliminary evaluation of Cognitive Bias Modification for Interpretation (CBM-I) and Approach Avoidance Training (AAT) as augmentations to treatment as usual for OCD and related disorders. CBM-I refers to computerized interventions designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. In AAT, automatic approach tendencies toward feared stimuli are re-trained. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I and AAT.

Adults with obsessive compulsive disorder (OCD) and related disorders will be recruited from a treatment program for these disorders and participants will be randomly assigned to either receive: 1) eight sessions of CBM-I or eight sessions of psychoeducation as a control condition, or 2) AAT or eight sessions of an inactive (sham) version of the AAT training.

Eligibility

Inclusion Criteria:

  • Currently receiving treatment at the McLean Hospital OCD Institute
  • For CBM-I condition only: report a score of at least 131 on the Obsessive Beliefs Questionnaire-44 upon admission to the OCD Institute
  • For AAT condition only: endorse score of at least 7 on the DOCS subscale #1 (contamination subscale) upon admission to the OCD Institute
  • Able to complete a computer task for 20 minutes
  • Consent to main OCD Institute study protocol

Exclusion Criteria:

  • Currently undergoing electroconvulsive therapy (ECT)
  • Current symptoms of acute mania or psychosis
  • A reported diagnosis at admission of a psychotic disorder
  • History of traumatic brain injury

Study details
    Obsessive-Compulsive Disorder
    Obsessive-compulsive Disorders and Symptoms

NCT03799419

Mclean Hospital

20 August 2025

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