Overview
The aim of the study is to demonstrate a significant improvement in quality of life specific to patients with fibromyalgia syndrome in patients with fibromyalgia syndrome with comorbid posttraumatic stress disorder, treated with reconsolidation blockade.
Patients receive a treatment with propranolol associated with reconsolidation blockade of traumatic story once a week during 6 weeks, with evaluation at inclusion and at 3 months.
Eligibility
Inclusion Criteria:
- Adult over 18 years old
- Diagnosis of fibromyalgia syndrome according to ACR 2016 criteria
- PCL-5 > 44 suggesting the presence of a comorbid post-traumatic stress disorder
- Meet the DSM-5 criteria for post-traumatic stress disorder secondary to exposure to a traumatic event according to DSM-5 criteria, both unique or repeated and regardless of the date or location of the traumatic event.
- Pain relief treatment and/or psychotropic treatment stabilized for a period greater than or equal to two months.
- Signature of a consent form
- Patient able to understand and read french
Exclusion Criteria:
- Psychotic disorders
- Unstable bipolar disorder
- Patients with a systolic blood pressure < 100 mmHg or heart rate < 55 as established during the initial visit
- Significant anormal ECG
- Medical contraindication to taking propranolol
- Adverse reactions or previous intolerances to a beta blocker
- Current intake of another beta blocker which can not be stopped during the protocol, regardeless the galenic.
- Current intake of a drug with potential contraindication with the propranolol, according to the summary of product characteristics of the propranolol.
- Patient under legal protection, under guardianship or under curatorship
- Patient having suffered a head trauma for less than a year or with clinical symptoms and neurological sequelae
- Known severe suicide risk (MINI-S and medical exam)
- Current opioid addiction or alcohol dependence
- Patients treated for less than 2 months with antidepressants or painkillers
- Patients unafiliated to a social health care
- Woman who is pregnant or breast-feeding or whithout efficient contraception