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Hemophagocytosis in Critically Ill Adult Patients

Hemophagocytosis in Critically Ill Adult Patients

Recruiting
18-90 years
All
Phase N/A
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Overview

The purpose of the study is to find out whether non-responsiveness to therapeutic recombinant human granulocyte colony-stimulation factor (rhG-CSF) is associated with hemophagocytosis in critically ill adult patients with cytopenias.

Description

In children with bi- or pancytopenia, hemophagocytosis is known as life-threatening hemophagocytic lymphohistiocytosis (HLH). The purpose of the study is to find out whether adult patients with bicytopenia or pancytopenia fulfilling the clinical HLH criteria used in children reflect life-threatening hemophagocytosis and whether hemophagocytosis is associated with responsiveness to recombinant human granulocyte colony-stimulation factor (rhG-CSF) or not.

Eligibility

Inclusion Criteria:

  • age > 18 years
  • critically ill adult patients
  • leukopenia and thrombocytopenia
  • rhG-CSF therapy

Exclusion Criteria:

  • life expectancy < 24 hours
  • inclusion in other studies
  • trauma patients with reanimation on scene or immediately dying on hospital admission
  • pregnancy
  • hematologic disorder, malignancy
  • high dose corticosteroid treatment or chemotherapy

Study details
    Hemophagocytosis

NCT01913938

University of Ulm

25 January 2024

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