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A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

Recruiting
18 years of age
Both
Phase 3

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Overview

The purpose of this study is to learn about the safety and effects of the study medicine ritlecitinib for the possible treatment of nonsegmental vitiligo. Vitiligo causes white patches on your skin when the cells that give your skin color are destroyed. Nonsegmental means that it can affect both sides of the body such as both knees and both hands.

Ritlecitinib has been tested in earlier clinical studies and has a favorable safety profile. At present there are no approved medications taken by mouth to treat nonsegmental vitiligo.

This study is seeking participants who:

  • Are 18 years of age or older.
  • are confirmed to have nonsegmental vitiligo for at least 3 months.
  • Are willing to stop all other treatments that they may be taking for vitiligo.

In this study participants will be chosen by chance, like drawing names out of a hat to receive 1 of 3 treatments:

•Part I where two different amounts of ritlecitinib (50 mg and 100 mg) are taken once daily. It will be compared to placebo. Placebo is a dummy capsule. It doesn't have any medicine used in the study.

Participants receiving placebo who have not responded to treatment after 52 weeks will be given 100 milligrams or 50 milligrams of ritlecitinib for the remaining 52 weeks of the study.

• In Part II, participants will only receive 100 milligrams of ritlecitinib. About 1000 participants will take part in Part I and around 450 in Part II globally. The study will compare the experiences of people receiving ritlecitinib to those of the people who do not. This will help see if ritlecitinib is safe and effective.

People in Part I will be in this study for about 26 months and people in Part II will be in this study for about 14 months. During the study, participants in part I will need to visit the study site at least 17 times. In part II, participants will visit at least 11 times.

Participants will undergo various tests and procedures such as:

  • vitiligo rating,
  • physical examinations,
  • hearing tests,
  • blood tests,
  • x-ray,
  • ECG,
  • photographs of areas with vitiligo. Participants will be asked to complete questionnaires about their vitiligo.

Description

Study B7981080 is a Phase 3 randomized, double-blind, multicenter study with a 52-week placebo-controlled period (Part Ia) followed by a double-blind 52-week extension period (Part Ib) that includes randomized dose-up/down titration and a de novo 52-week non-randomized open-label cohort (Part II), investigating the efficacy, safety, and tolerability of ritlecitinib 100 mg QD and 50 mg QD compared with placebo in adult participants with nonsegmental active or stable vitiligo

Eligibility

Inclusion Criteria:

  1. Participants aged 18 years (or the minimum age of consent in accordance with local regulations) or older (no upper age limit) at Screening.

    • Meeting reproductive criteria for female participants.

    Disease Characteristics:

  2. Eligible participants must have at both Screening and BL:
    • A clinical diagnosis of nonsegmental vitiligo for at least 3 months; and
    • BSA involvement 4% to 60% inclusive, excluding involvements at palms of the hands, soles of the feet, or dorsal aspect of the feet and
    • BSA ≥0.5% involvement on the face. Face is defined as including the area on the forehead to the original hairline, on the cheek to the jawline vertically to the jawline and laterally from the corner of the mouth to the tragus. Face will not include scalp, ears, neck, or surface area of the lips, but will include the nose and the eyelids; and
    • F-VASI ≥0.5 and T-VASI ≥3; and
    • Either active or stable nonsegmental vitiligo at Screening and BL visits. All participants who do not have the features of active vitiligo (defined below) will be classified as having stable disease.

Active vitiligo is defined as:

             Participants will be classified as having active vitiligo based on the presence of at
             least one active lesion at BL defined as one of the following:
               -  New/extending lesions(s) in the 3 months prior to Screening visit (confirmed by
                  photographs or medical record);
               -  Confetti-like lesion(s); Confetti-like depigmentation is characterized by the
                  presence of numerous 1-mm to 5-mm depigmented macules in clusters;
               -  Trichrome lesion(s); Trichrome lesions have a hypopigmented zone of varying width
                  between normal and completely depigmented skin, resulting in 3 different hues of
                  skin;
               -  Koebner phenomenon/phenomena (excluding Type 1 [history based on isomorphic
                  reaction]). The Koebner phenomenon manifests as depigmentation at sites of
                  trauma, usually in a linear arrangement.
             Stable vitiligo is defined as:
             • Participants will be classified as having stable vitiligo based on an absence of
             signs of active disease. All participants who do not have the features of active
             vitiligo (defined above) will be classified as having stable disease.
             Eligibility is determined at Screening and Baseline based on the resulting scores from
             the local in-person reads of F-VASI, T-VASI, and BSA.
          3. Additional inclusion criteria are:
               -  If receiving concomitant medications for any reason other than vitiligo,
                  participant must be on a stable regimen, which is defined as not starting a new
                  drug or changing dosage within 7 days or 5 half-lives (whichever is longer) prior
                  to Day 1. Participant must be willing to stay on a stable regimen during the
                  duration of the study.
               -  Must agree to stop all other treatments for vitiligo from Screening through the
                  final follow-up visit.
        Exclusion Criteria:
        Medical Conditions:
          1. Any medical or psychiatric condition including recent (within the past year) or active
             suicidal ideation/behavior or laboratory abnormality that may increase the risk of
             study participation or, in the investigator's judgment, make the participant
             inappropriate for the study.
             • Any psychiatric condition including recent or active suicidal ideation or behavior
             that meets defined criteria.
          2. Medical conditions pertaining to vitiligo and other diseases/conditions affecting the
             skin:
               -  Participants that have other types of vitiligo that do not meet criteria for
                  active or stable vitiligo as noted in inclusion criteria (including but not
                  limited to segmental vitiligo and mixed vitiligo).
               -  Currently have active forms of other hypopigmentation (including but not limited
                  to Vogt-Koyanagi-Harada disease, malignancy-induced hypopigmentation [melanoma
                  and mycosis fungoides], post-inflammatory hypopigmentation, pityriasis alba
                  [minor manifestation of atopic dermatitis], senile leukoderma [age-related
                  depigmentation], chemical/drug-induced leukoderma, ataxia telangiectasia,
                  tuberous sclerosis, melasma, and congenital hypopigmentation disorder including
                  piebaldism, Waardenburg syndrome, hypomelanosis of Ito, incontinentia pigmenti,
                  dyschromatosis symmetrica hereditarian, xeroderma pigmentosum, and nevus
                  depigmentosus). NOTE: Coexistence of halo nevus/nevi (also known as Sutton
                  nevus/nevi) is permitted.
               -  Currently have active forms of inflammatory skin disease(s) or evidence of skin
                  conditions (for example, but not limited to morphea, discoid lupus, leprosy,
                  syphilis, psoriasis, seborrheic dermatitis) at the time of the Screening or BL
                  Visit that in the opinion of the investigator would interfere with evaluation of
                  vitiligo or response to treatment.
               -  Leukotrichia in more than 33% of the face surface area affected with vitiligo
                  lesions or leukotrichia in more than 33% of the total body surface area affected
                  with vitiligo lesions.
               -  Have a superficial skin infection within 2 weeks prior to first dose on Day 1.
                  NOTE: participants may be rescreened after the infection resolves.
          3. General Infection History:
               -  Have a history of systemic infection requiring hospitalization, parenteral
                  antimicrobial, antiviral (including biologic treatment), antiparasitic,
                  antiprotozoal, or antifungal therapy, or as otherwise judged clinically
                  significant by the investigator within 6 months prior to Day 1.
               -  Have active acute or chronic infection requiring treatment with oral antibiotics,
                  antivirals, antiparasitics, antiprotozoals, or antifungals within 4 weeks prior
                  to Day 1. NOTE: participants may be rescreened after the infection resolves.
               -  Evidence or history of untreated, currently treated or inadequately treated
                  active or latent infection with Mycobacterium tuberculosis.
          4. Specific Viral Infection History:
               -  History (single episode) of disseminated HZ or disseminated herpes simplex or
                  recurrent (more than one episode of) localized, dermatomal HZ.
               -  Infected with HBV or HCV: all participants will undergo screening for HBV and HBC
                  for eligibility.
               -  Participants who are positive for HCVAb and HCV RNA will not be eligible for this
                  study.
               -  Have a known immunodeficiency disorder (including positive serology for HIV at
                  screening) or a first-degree relative with a hereditary immunodeficiency.
          5. Other Medical Conditions:
               -  Current or recent history of clinically significant severe, progressive, or
                  uncontrolled renal (including but not limited to active renal disease or recent
                  kidney stones), hepatic, hematological, gastrointestinal, metabolic, endocrine
                  (eg, untreated hypovitaminosis D or hypothyroidism), pulmonary, cardiovascular,
                  psychiatric, immunologic/rheumatologic or neurologic disease; or have any other
                  severe acute or chronic medical or psychiatric condition or laboratory
                  abnormality that may increase the risk associated with study participation or
                  investigational product administration, or interfere with the interpretation of
                  study results; or in the opinion of the investigator or Pfizer (or designee), the
                  participant is inappropriate for entry into this study, or unwilling/unable to
                  comply with study procedures and lifestyle requirements.
               -  History of severe allergic or anaphylactoid reaction to any kinase inhibitor or a
                  known allergy/hypersensitivity to any component (including excipients) of the
                  study intervention.
               -  Have hearing loss with progression over the previous 5 years, sudden hearing
                  loss, or middle or inner ear disease such as otitis media, cholesteatoma,
                  Meniere's disease, labyrinthitis, or other auditory condition that is considered
                  current, fluctuating, or progressive.
               -  Have a history of any lymphoproliferative disorder such as EBV-related
                  lymphoproliferative disorder, history of lymphoma, history of leukemia, or signs
                  and symptoms suggestive of current lymphatic or lymphoid disease.
               -  Abnormal findings on the Screening chest imaging (eg, chest x-ray). Chest imaging
                  may be performed up to 12 weeks prior to screening. Documentation of the official
                  reading must be located and available in the source documentation.
               -  Long QT Syndrome, a family history of Long QT Syndrome, or a history of TdP.
               -  Have any malignancies or have a history of malignancies with the exception of
                  adequately treated or excised nonmetastatic basal cell or squamous cell cancer of
                  the skin or cervical carcinoma in situ.
               -  Significant trauma or major surgery within 1 month of the first dose of study
                  drug or considered in imminent need for surgery or with elective surgery
                  scheduled to occur during the study.
             Prior/Concomitant Therapy:
          6. Have received any of the prohibited treatment regimens specified.
             Prior/Concurrent Clinical Study Experience:
          7. Previous administration with an investigational drug or vaccine that do not affect
             vitiligo within 4 weeks of Day 1 [Baseline] or within 5 half-lives, whichever is
             longer.
             Diagnostic Assessments:
             Any of the following abnormalities in clinical laboratory tests at Screening, as
             assessed by the study-specific laboratory and, if deemed necessary, confirmed by a
             single repeat:
          8. Renal impairment
          9. Hepatic dysfunction
         10. Other laboratory abnormalities
         11. Standard 12-lead ECG that demonstrates clinically relevant abnormalities
             Other Exclusion Criteria:
         12. Investigator site staff directly involved in the conduct of the study and their family
             members, site staff otherwise supervised by the investigator, and sponsor and sponsor
             delegate employees directly involved in the conduct of the study and their family
             members.
         13. In South Africa only participants are excluded without one of the following:
               -  Document evidence form a health professional of having received varicella
                  vaccination (two doses); or
               -  Evidence of prior exposure to VZV based on serological testing (ie a positive VZV
                  IgG Ab result) at Screening.

Study details

Stable Nonsegmental Vitiligo, Active Nonsegmental Vitiligo

NCT06072183

Pfizer

14 June 2024

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