Overview
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
Description
This will be a cross sectional study and will include male and female, young (15-40-years) well characterized patients with early (eGFR>70mL/min/1.73m2) ADPKD. Patients with different classes of disease severity will be selected using the ADPKD imaging classification. The study will include 60 class-1 (A-E) patients (N=12 per each sub-class).
Eligibility
Inclusion Criteria:
- ADPKD (based on Ravine et al. criteria)
- Class 1 A-E according to imaging classification
- Male and female subjects 15 - 40 years of age
- Estimated GFR> 70 mL/min/1.73 m2 (CKD-EPI)
- Ability to provide written, informed consent
Exclusion Criteria:
- Class 2 according to imaging classification
- Concomitant systemic disease affecting the kidney
- Diabetes mellitus
- Predicted urine protein excretion in >1 g/24 hrs
- Use of antioxidants i.e. vitamins, Nrf2 activators
- Abnormal urinalysis