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Preoperative Corticosteroids in Autoimmune Thyroid Disease

Recruiting
18 years of age
Both
Phase 4

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Overview

This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.

Eligibility

  • Inclusion Criteria:
     ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb,
     TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease.
  • Exclusion Criteria:
    • Pediatric patients < 18
    • Prior treatment with RAI
    • Prior neck surgeries
    • Known diagnosis of thyroid cancer
    • Diabetic patients on medications
    • A history of adverse reactions to corticosteroids.
    • Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.

Study details

Graves Disease, Hashimoto Disease

NCT05435547

Indiana University

10 May 2025

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