Overview
The aim of the study is to compare the efficacy of per-oral endoscopic myotomy (POEM) to the efficacy of pneumodilation as the initial treatment of symptomatic idiopathic achalasia. It is hypothesized that POEM has a higher long-term efficacy than pneumodilation in treatment of therapy-naive patients with idiopathic achalasia.
Eligibility
Inclusion Criteria:
- Between 18 and 75 yr of age
- Manometric diagnosis of achalasia
- Eckardt score > 3
- Informed consent
Exclusion Criteria:
- Severe cardio-pulmonary disease or other serious disease leading to unacceptable surgical risk previous treatment, except treatment with nitroderivatives, Ca++ channel blockers or sildenafil, or dilation with Savary bougies or balloons of 2 cm diameter or smaller.
Pseudo-achalasia Mega-esophagus (> 7 cm) and/or sigmoid-like esophagus Previous esophageal
or gastric surgery (except for gastric perforation) Not capable to fill out questionnaires
(f.e. due to language barrier) Not available for follow-up Esophageal diverticula in the
distal esophagus Malignant or premalignant esophageal lesions Patients with liver cirrhosis
and/or esophageal varices Pregnancy