Overview
The Change Database is a prospective, observational multi-center disease registry, which will collect data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China. It aims to illustrate the epidemiology, management and long-term outcomes of CTEPH.
Description
18 CTEPH centers will be enrolled in the study. The epidemiology, diagnosis，treatments (pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA) and targeted medical therapy), and long-term prognosis of CTEPH will be evaluated.
Eligibility
Inclusion Criteria:
- Patients must be diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH)
- Patients must be willing to provide informed consent
- Patients must meet the following criteria for CTEPH:
a mean pulmonary artery pressures (mPAP) ≥20 mmHg combined with a pulmonary vascular
resistance (PVR) ≥ 3 WU and pulmonary arterial wedge pressure (PAWP)≤ 15 mmHg documented at
right heart catheterization with radiographic evidence of organized thrombi involving the
pulmonary arteries after 3 months of effective anticoagulation.
Exclusion Criteria:
1. Main cause of PH other than CTEPH
2. Participation in a therapeutic clinical trial with an unknown drug;
3. Withdrawal or lack of informed consent.