Overview

Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.

Eligibility

Common Criteria for inclusion :

• Signature of written consent
• Subject affiliated or entitled to a social security scheme

Inclusion Criteria: Patients with restrictive anorexia nervosa (30 subjects).

• Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI < 17.5 kg/ m², amenorrhea
• Absence of food compulsions and purges
• Subgroup 1 (15 subjects) : STAI Y2 anxiety score > 61
• Subgroup 2 (15 subjects) : STAI Y2 anxiety score < 51

Inclusion criteria - Female control subjects (15 subjects)

• BMI between 18.5 and 25 kg/ m²
• Absence of a psychological profile of eating disorder or other psychiatric disorders.

Exclusion Criteria:

• Subjects with an oral contraception and breastfeeding woman
• Subject with heart failure
• Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, ...),dopaminergic drugs.
• Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination.
• Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia).
• Subjects unable to sign written consent for participation in the study.
• Subject deprived of liberty by a judicial or administrative decision