Overview
This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
Description
The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.
Eligibility
Inclusion Criteria:
- Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation
- 18-80 years old
- The anteroposterior diameter of the left atrium is less than 50mm via TTE
- Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists
- Patient consents to ablation treatment
Exclusion Criteria:
- Intra-atrial thrombus detected by TEE
- Hyperthyroidism
- Previous radiofrequency ablation for atrial fibrillation