Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer

Overview

To increase the efficacy of neoadjuvant PD-1/PD-1 checkpoint inhibitor in local advanced rectal cancer (LARC), we propose preoperative arterial infusion of Tirellizumab and oxaliplatin followed by tumor artery embolization with concurrent chemoradiotherapy as neoadjuvant regimen for LARC.

Description

Based our previous multi-center randomized controlled study (Preoperative arterial perfusion Chemo- embolization combined with radiotherapy for locally advanced rectal cancer, NCT03601156), the idea of "preoperative arterial chemo-immuno-embolization combined with radiotherapy for locally advanced rectal cancer (CIETAI-R)" was proposed. This is also the serial study of CIETAI that explore the efficacy of tumor arterial chemo-immuno-embolization in lung cancer, LARC, metastatic liver cancer.

Eligibility

Inclusion Criteria:

• Local advanced Rectal cancer: stage T3/4NanyM0 or T1-2N+M0.
• Ages: 18 to 75.
• No previously received chemotherapy drugs and radiation therapy.
• ECOG score: 0 - 2.
• Appropriate organ function, as defined below:

        (Hematology and blood biochemistry examination must be completed within 7 days before the
        registration date) i) White blood cell count ≥ 4,000/mm3. ii) Neutrophil count ≥ 1,500/mm3.
        iii) Hemoglobin ≥ 10 g/dL. iv) Platelet count ≥ 100,000/mm3. v) Total bilirubin ≤ 1.5 times
        the upper limit of normal (ULN). vi. Liver function Index (AST & ALT) ≤ 1.5 times the upper
        limit of normal (ULN).
        vii. Serum creatinine ≤1.5 times the upper limit of normal or creatinine clearance ≥60
        ml/min.
          -  Tolerance of orally administration of capecitabine.
          -  Can understand the study, have good compliance, cooperate with follow-up.
        Exclusion Criteria:
          -  Severe allergic reaction to humanized antibodies or fusion proteins;
          -  Hypersensitivity to any component contained in contrast agent or granule embolic
             agent;
          -  Diagnosed with an immune deficiency or is receiving systemic glucocorticoid therapy or
             any other form of immunosuppressive therapy within 14 days prior to the first
             administration of the study, allowing the use of physiological doses of
             glucocorticoids (≤10mg/ day of prednisone or equivalent);
          -  Active, known, or suspected autoimmune diseases (such as interstitial pneumonia,
             colitis, hepatitis, pituitaritis, vasculitis, nephritis, hypothyroidism, including,
             but not limited to, these diseases or syndromes). Subjects who have type 1 diabetes,
             hypothyroidism requiring hormone replacement therapy, skin conditions that do not
             require systemic treatment (e.g., vitiligo, psoriasis, or hair loss), or conditions
             that are not expected to recur in the absence of external triggers may be enrolled;
          -  Pre-existing severe heart disease, including congestive heart failure, uncontrolled
             high-risk arrhythmias, unstable angina pectoris, myocardial infarction, and severe
             heart valve disease;
          -  Active hepatitis B (HBV DNA ≥ 2000IU/ml or 104copies/ml), hepatitis C (hepatitis C
             antibody positive, and HCV-RNA higher than the lower limit of analysis).
          -  Active tuberculosis (TB) infection. Patients with a history of active tuberculosis
             infection within the previous 1 year should be excluded, even if they have been
             treated; Patients with a history of active tuberculosis infection more than 1 year ago
             should also be excluded unless the duration and type of antituberculosis therapy
             previously used is demonstrated to be appropriate.
          -  Brain metastases accompanied by symptoms or symptoms controlled for less than 2
             months;
          -  Received major surgical treatment, open biopsy, or significant traumatic injury within
             28 days prior to enrollment;
          -  Pregnant or lactating female patients (women of childbearing age must confirm that the
             pregnancy test is negative within 7 days before the first administration of the drug,
             if it is positive, ultrasound examination must be performed to rule out pregnancy),
             subjects of childbearing age refuse to accept contraceptive measures; Combined with
             other malignancies, except cured skin basal cell carcinoma or skin squamous cell
             carcinoma or in situ carcinoma of any other site
          -  Patients with any physical signs or history of bleeding, regardless of severity;
             Non-healing wounds, ulcers, or fractures were present in patients with any bleeding or
             bleeding events ≥CTCAE grade 3 during the 4 weeks prior to grouping;
          -  Arteriovenous thrombosis events within 6 months, such as cerebrovascular accidents
             (including temporary ischemic attacks), deep vein thrombosis and pulmonary embolism;
          -  Dementia, altered mental status or any mental illness that would prevent understanding
             or giving informed consent or completing the questionnaire
          -  Other serious concomitant diseases judged by the investigator.