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A Study of LY3454738 in the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis

Not Recruiting
18 - 70 years of age
Both
Phase 2

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Overview

The main purpose of this study is to describe the efficacy and safety of LY3454738 in adult participants with moderate-to-severe atopic dermatitis (AD).

Eligibility

Inclusion Criteria:

  • Are candidates for systemic therapy.

ISA specific:

  • Have moderate-to-severe AD, defined as meeting all of the following criteria, at the first dosing visit:
    • EASI score greater than or equal to (≥)16
    • vIGA-AD score ≥3, and
    • ≥10% of BSA involvement (per EASI BSA).
  • Have applied at least 1 emollient every day for at least 2 weeks before the day of

    the first dose of study intervention in this ISA and agree to daily use of at least 1 emollient continuously throughout the study.

Exclusion Criteria:

ISA specific:

  • Have, in the screening period, any of the skin conditions, infections, or medical conditions listed under master IMMB.
  • Are currently being treated with topical or systemic therapy
  • Recent treatment with experimental (biologics and/or small molecules) - doesn't apply for subset of participants who must have been exposed to biologics and/or small molecules.

Study details

Atopic Dermatitis

NCT05911841

Eli Lilly and Company

25 January 2025

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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