Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)

Overview

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care

Description

This is a randomized, double-blind, double dummy, parallel group, multicenter 24 to 52 week variable length study to assess the efficacy and safety of budesonide, glycopyrronium, and formoterol fumarate metered dose inhaler (MDI) relative to budesonide and formoterol fumarate MDI and Symbicort® pressurized MDI in adult and adolescent participants with inadequately controlled asthma. Approximately 2200 participants will be randomized globally.

Eligibility

Inclusion Criteria:

1. 12 to 80 years of age, male and female, BMI <40 kg/m2; females must be not of childbearing potential or using a form of highly effective birth control.
2. Documented history of physician-diagnosed asthma > and/or = 1 year prior to V1.
3. Regularly using a stable daily ICS/LABA regimen (including a stable ICS dose) with medium-to-high ICS doses for at least 4 weeks prior to V1.
4. ACQ-7 total score ≥1.5 at Visits 1, 3, and 5 (pre-randomization).
5. FEV1 % (assessed as an average of the 60 and 30 minute pre-dose assessments) predicted normal at V1, 2, 3, 4, and 5 (pre-randomization)
   • Participants ≥ 18 years of age: < 80%
   • Participants 12 to <18 years of age: < 90%
6. FEV1 post-albuterol at V2 or V3 (if repeat needed).
   • Participants > and/or = 18 years of age: Increase > and/or = 12% and > and/or = 200 mL.
   • Participants 12 to <18 years of age: Increase =12% either in the 12 months prior to Visit 1 or at Visit 2, or at Visit 3.
   • Note: Even if there is documented history of reversibility, all participants must be assessed for reversibility at Visit 2 (and Visit 3, if reversibility is not demonstrated at Visit 2) to provide reversibility baseline data for characterization.
7. Willing and, in the opinion of the Investigator, able to adjust current asthma

   therapy, as required by the protocol.

8. Demonstrate acceptable MDI/pMDI administration technique.
9. Received no asthma medication other than run-in BFF MDI BID and albuterol as needed during screening (except for allowed medications as defined in Table 9 and systemic corticosteroid or ICS for the treatment of an asthma exacerbation).
10. eDiary 14-day compliance ≥70% during screening (defined as completing the daily eDiary for any 10 mornings and any 10 evenings and answering "Yes" to taking 2 puffs of run-in BFF MDI for any 10 mornings and 10 evenings in the last 14 days prior to randomization).
11. No respiratory infection in the 4 weeks prior to randomization, or asthma exacerbation treated with systemic corticosteroid and/or additional ICS treatment in the 4 weeks prior to randomization.

Exclusion Criteria:

1. Completed treatment for respiratory infection or asthma exacerbation with systemic corticosteroids within 4 weeks of V1.

        2a. Participants where, in the opinion of the Investigator, treatment with biological
        therapy for asthma would be appropriate.
        2b. Any marketed or investigational biologics within 3 months or 5 half-lives of V1,
        whichever is longer and must not be used during study duration.
        3. Current smokers, former smokers with >10 pack-years history, or former smokers who
        stopped smoking <6 months prior to V1 (including all forms of tobacco, e-cigarettes or
        other vaping devices, and marijuana).
        4. Current evidence of Chronic Obstructive Pulmonary Disease (COPD).
        5a. Oral and IV corticosteroid use (any dose) within 4 weeks of V1.
        5b. Use of systemic corticosteroids for any other reason except for the acute treatment of
        severe asthma exacerbation is prohibited for the duration of the study.
        5c. Depot corticosteroid use for any reason within 3 months of V1.
        6. Use of Long-Acting Muscarinic Antagonist (LAMA), either alone or as part of an inhaled
        combination therapy, in the 12 weeks prior to V1.
        7. Use of oral beta2-agonist within 3 months of V1.
        8. Use of any immunomodulators or immunosuppressive medication within 3 months or 5
        half-lives, whichever is longer, and must not be used during the study duration.
        9. Narrow angle glaucoma not adequately treated and/or change in vision that may be
        relevant, in the opinion of the Investigator, within 3 months of Visit 1.
        10. Life-threatening asthma defined as a history of significant asthma episode(s) requiring
        intubation associated with hypercapnia, respiratory arrest, hypoxic seizures, or
        asthma-related syncopal episode(s).
        11. Hospitalization for asthma within 2 months of Visit 1.
        12. Known history of drug or alcohol abuse within 12 months of Visit 1.
        13. Regular use of a nebulizer or a home nebulizer for receiving asthma medications.
        14. Using any herbal products by inhalation or nebulizer within 4 weeks of Visit 1 and does
        not agree to stop during the study duration.
        15. Participation in another clinical study with a study intervention administered in the
        last 30 days or 5 half-lives, whichever is longer. Any other study intervention that is not
        identified in the protocol is prohibited for use during study duration.
        16. Participants with a known hypersensitivity to beta2-agonists, corticosteroids,
        anticholinergics, or any component of the MDI or pMDI.
        17. Study Investigators, sub-Investigators, coordinators, and their employees or immediate
        family members.
        18. For women only - currently pregnant (confirmed with positive highly sensitive pregnancy
        test), breast-feeding, or planned pregnancy during the study or not using acceptable
        contraception measures, as judged by the Investigator.
        Please refer to the study protocol for the complete inclusion and exclusion criteria list.